BALANCING OPPORTUNITY: BETWEEN THE PRESUMPTION OF INNOCENCE AND RES JUDICATA


Development and Validation of an LC–MS/MS Method for Quantifying Gabapentin in Plasma: Application to a Pharmacokinetic Study in Cats

Gabapentin (GBP), a γ-aminobutyric acid analogue used for neuropathic pain and epilepsy, can reduce cat stress and improve veterinary exam compliance.A sensitive LC-MS/MS assay was established and Lacrosse - Other - Miscellaneous rigorously validated for quantifying GBP in feline plasma.The method employed acetonitrile-mediated protein precipitati

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Long versus short-term opioid therapy for fibromyalgia syndrome and risk of depression, sleep disorders and suicidal ideation: a population-based, propensity-weighted cohort study

Objective Fibromyalgia syndrome (FMS) is characterised by widespread pain and is associated with mood disorders such as depression as well as poor sleep quality.These in turn have been linked to increased risk of suicidal ideation.Clinical guidelines generally do not recommended opioids in FMS, but they are routinely prescribed to a considerable pr

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